Discovery of the novel compound PyrzA provides a new way to relieve the stress of hypoxia in living organisms!

Research results from the Faculty of Agriculture, Saga University, the United Graduate School of Agricultural Science, Kagoshima University, the Graduate School of Advanced Health Sciences, Saga University, the Tohoku University New Industry Creation Incubation Center, and the Tohoku University Graduate School of Medicine: “Discovery of a novel compound, PyrzA, which provides a new way to relieve the stress of hypoxia in the human body has been published.

In our body, small emboli in the microenvironment are constantly forming and dissolving while maintaining homeostasis. Embolism formation is one of the causes of ischemic diseases such as myocardial infarction and stroke, and methods of prevention and intervention for early hypoxic injury are being developed worldwide.

The functional analysis of PyrzA against hypoxic injury was performed in cultured cells and individual mice using the existing drug roxadustat (FG-4592) as a benchmark, and its ability to protect against hypoxic injury was demonstrated biochemically and physiologically, although weakly for roxadustat. The discovery of PyrzA provides a new fundamental framework for traditional PHD inhibitors and is expected to lead to the creation of compounds that act specifically on PHD isoforms.